Some With Autism Diagnosis Can Recover, Study Finds

Doctors have long believed that disabling autistic disorders last a lifetime, but a new study has found that some children who exhibit signature symptoms of the disorder recover completely.

The study, posted online on Wednesday by the Journal of Child Psychology and Psychiatry, is the largest to date of such extraordinary cases and is likely to alter the way that scientists and parents think and talk about autism, experts said.

Researchers on Wednesday cautioned against false hope. The findings suggest that the so-called autism spectrum contains a small but significant group who make big improvements in behavioral therapy for unknown, perhaps biological reasons, but that most children show much smaller gains. Doctors have no way to predict which children will do well.

Researchers have long known that between 1 and 20 percent of children given an autism diagnosis no longer qualify for one a few years or more later. They have suspected that in most cases the diagnosis was mistaken; the rate of autism diagnosis has ballooned over the past two decades, and some research suggests that it has been loosely applied.

The new study should put some of that skepticism to rest.

“This is the first solid science to address this question of possible recovery, and I think it has big implications,” said Sally Ozonoff of the MIND Institute at the University of California, Davis, who was not involved in the research. “I know many of us as would rather have had our tooth pulled than use the word ‘recover,’ it was so unscientific. Now we can use it, though I think we need to stress that it’s rare.”

She and other experts said the findings strongly supported the value of early diagnosis and treatment.

In the study, a team led by Deborah Fein of the University of Connecticut at Storrs recruited 34 people who had been diagnosed before the age of 5 and no longer had any symptoms. They ranged in age from 8 to 21 years old and early in their development were in the higher-than-average range of the autism spectrum. The team conducted extensive testing of its own, including interviews with parents in some cases, to gauge current social and communication skills.

The debate over whether recovery is possible has simmered for decades and peaked in 1987, when the pioneering autism researcher O. Ivar Lovaas reported that 47 percent of children with the diagnosis showed full recovery after undergoing a therapy he had devised. This therapy, a behavioral approach in which increments of learned skills garner small rewards, is the basis for the most effective approach used today; still, many were skeptical and questioned his definition of recovery.

Dr. Fein and her team used standardized, widely used measures and found no differences between the group of 34 formerly diagnosed people and a group of 34 matched control subjects who had never had a diagnosis.

“They no longer qualified for the diagnosis,” said Dr. Fein, whose co-authors include researchers from Queens University in Kingston, Ontario; Children’s Hospital of Philadelphia; the Institute of Living in Hartford; and the Child Mind Institute in New York. “I want to stress to parents that it’s a minority of kids who are able to do this, and no one should think they somehow missed the boat if they don’t get this outcome.”

On measures of social and communication skills, the recovered group scored significantly better than 44 peers who had a diagnosis of high-functioning autism or Asperger’s syndrome.

Dr. Fein emphasized the importance of behavioral therapy. “These people did not just grow out of their autism,” she said. “I have been treating children for 40 years and never seen improvements like this unless therapists and parents put in years of work.”

The team plans further research to learn more about those who are able to recover. No one knows which ingredients or therapies are most effective, if any, or if there are patterns of behavior or biological markers that predict such success.

“Some children who do well become quite independent as adults but have significant anxiety and depression and are sometimes suicidal,” said Dr. Fred Volkmar, the director of the Child Study Center at the Yale University School of Medicine. There are no studies of this group, he said.

That, because of the new study, is about to change.

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FAA grounds entire fleet of Boeing 787s

Federal officials say they are temporarily grounding Boeing's 787 Dreamliners until the risk of possible battery fires is addressed.

Federal regulators have grounded all U.S. Boeing 787 Dreamliner passenger jets, a potentially devastating setback for the company's troubled new flagship airliner.

The move Wednesday by the Federal Aviation Administration left airlines reeling, seeking ways to accommodate delayed passengers. Boeing Co. stock fell on the news in after-hours trading.

The order came Wednesday after a 787 operated by a Japanese carrier, All Nippon Airways, made an emergency landing in southwestern Japan. The crew reported an unusual smell in the cabin, and indicators in the cockpit told pilots there was a problem related to an onboard lithium-ion battery.

FAA statement on Boeing 787 grounding 

Such batteries were also involved in a fire last week aboard a parked 787 in Boston operated by Japan Airlines.

The Japanese carriers — which own 24 of the 50 Dreamliners flying today — decided to remove all of their 787s from service indefinitely out of safety concerns. That move led to the FAA's extraordinary grounding order.

The plane is assembled at Boeing's Everett, Wash., factory, but the bulk of the large components arrive from suppliers around the world pre-assembled. There are about 50 suppliers in California alone.

"This is clearly a black eye and hiccup for Boeing," said Richard Phillips, managing director at Janes Capital Partners, an Irvine-based aerospace and defense investment bank. "It's clearly related to the batteries.... It could mean significant reengineering work that … could take a long time."

Boeing Chief Executive Jim McNerney said in a statement that the company is working with the FAA to "find answers as quickly as possible."

"The company is working around the clock with its customers and the various regulatory and investigative authorities," he said. "We are confident the 787 is safe, and we stand behind its overall integrity."

The FAA's decision came less than a week after U.S. Transportation Secretary Ray LaHood and FAA chief Michael Huerta deemed the plane safe to fly. The 787 has experienced a series of mishaps including a fuel leak and the Boston fire. However, the FAA had allowed the planes to continue to operate while it launched an unusual and sweeping evaluation of the way Boeing designs, manufactures and assembles the aircraft.

At issue is the Dreamliner's electrical systems and power-distribution panels, which involves pervasive use of lithium-ion batteries, which have been involved in fires and can also be found in cellphones and electric automobiles. The Dreamliner is the first large commercial aircraft to use the technology on such a large scale.

In a statement, the FAA said that the grounding order is aimed to "address a potential battery fire risk in the 787 and require operators to temporarily cease operations. Before further flight, operators of U.S.-registered Boeing 787 aircraft must demonstrate to the Federal Aviation Administration that the batteries are safe."

The FAA order is expected to be followed by carriers worldwide.

Boeing's use of lithium-ion batteries, made by Kyoto, Japan-based GS Yuasa Corp., were called into question when a smoldering fire was discovered last week on the underbelly of a Dreamliner operated by Japan Airlines after the 173 passengers and 11 crew members had deplaned at the gate.

In the latest incident involving All Nippon Airways, smoke was seen swirling from the right side of the cockpit. All 137 passengers and crew were evacuated from the aircraft and slid down the Dreamliner's emergency slides. Video of the event was captured by an onboard passenger and has been broadcast worldwide.

The FAA has been aware of the flammability of lithium-ion batteries for years. Still when the agency was certifying the Dreamliner for flight operation, it issued special conditions for lithium-ion battery installations on the Dreamliner because regulations don't cover this technology.

"At present, there is limited experience with use of rechargeable lithium-ion batteries in applications involving commercial aviation. However, other users of this technology, ranging from wireless telephone manufacturing to the electric vehicle industry, have noted safety problems with lithium ion batteries. These problems include overcharging, over-discharging, and flammability of cell components," the FAA wrote at the time.

The FAA has issued scathing assessments of lithium-ion batteries for starting fires.

In October 2011, the FAA issued an airworthiness directive to owners of Cessna Aircraft Co.'s Model 525C airplanes that required them to swap out the lithium-ion batteries with other batteries.

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Family of man killed by Santa Ana police disputes city's explanation

The family of a man killed by police in Santa Ana disputed the official chain of events leading to his shooting, saying the 39-year-old had fallen asleep in his parked car and was startled when officers began banging on his vehicle.

The death of Binh Van Nguyen has stirred protests and rumors, fanned by coverage on Vietnamese radio and conversation at local coffeehouses.

In a public outreach effort Monday, Santa Ana city leaders — including Mayor Miguel Pulido and interim Police Chief Carlos Rojas — held a town hall meeting to respond to the rumors and offer reassurance that the shooting is being investigated.

"We hope to show the community we are listening," Cpl. Anthony Bertagna said.

Police said they were forced to open fire with semiautomatic handguns when Nguyen tried to drive his white Toyota toward them in the early hours of last Friday.

Patrol officers cruising through a west Santa Ana neighborhood reported that they first spotted Nguyen sitting in the back seat of his parked car in the 200 block of Maxine Street. As two uniformed men approached, he jumped into the front seat, police said.

The officers said they asked him to exit the car, but instead he gunned it toward them, Bertagna said.

The area where the 12:45 a.m. incident unfolded is a haven for gang activity and drugs, police said.

But family members countered the official version of what happened.

"The crime scene photos show Binh's car in a stationary position curbside, with little or no room to maneuver," the Nguyens said in a statement released by their attorney, Michael Guisti.

The family asserted that the officers were not wearing uniforms and that Nguyen — startled from his sleep — had no way of knowing they were policemen.

"We are grief-stricken beyond words. Binh was a gentle and kind man with a warm personality," the family said.

Supporters staged a peaceful protest Sunday at the scene where Nguyen, who worked in a dry-cleaning shop, was shot. He is survived by his wife and two sons, ages 13 and 7.

"They need to show the greater community that this is a tragedy and police have questions to answer," Guisti said.

Both officers involved in the fatality, one a veteran and the other described as "experienced" but new to the department, are on leave but expected to return to duty.

Police found drug paraphernalia in Nguyen's car, Bertagna said.

anh.do@latimes.com

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Tablet Too Small? Try Lenovo’s 27-Inch ‘Table PC’

Google’s aptly-named Nexus 7 tablet made a splash when it debuted last year, at $ 199 and with a screen 7 inches across. Apple soon released its own iPad Mini to join the increasingly crowded world of miniature tablets, which — at about half the size of a regular iPad — are so small as to be pocketable.

Other manufacturers, however, aren’t taking the “smaller is better” route. Microsoft‘s Surface tablet debuted with a 10.6-inch screen, almost an inch across more than the iPad. And now at the recent Consumer Electronics Show, at least two companies were showing off “tablets” the size of an HDTV.

The “IdeaCentre Horizon Table PC”

That’s the actual name of Lenovo‘s new product, which Lenovo is calling an “interpersonal PC” (yes, that is an interpersonal Personal Computer, in case you were wondering). It’s a Windows 8 tablet, with a screen 27 inches across. It can apparently serve as an iMac-style, all-in-one desktop just fine, but Lenovo wants people to use it flat on their tables, like in a promo video which evokes the original Microsoft Surface.

A $ 10,000 bathtub

That’s basically what the first Surface amounted to — the Microsoft prototype of years ago, which never saw widespread use. It was a super-expensive, bathtub-sized table, with a Windows Vista PC inside and a camera array which optically scanned its top surface. It wasn’t a true touchscreen, in other words, so much as an expensive hack that was mostly just good for demos and reminding people of the desks in “Tron.”

Lenovo’s “Table PC” is smaller than that Surface, but will also be a lot cheaper when it comes out “beginning in early summer,” at $ 1,699. And like in those giddy tech demos, it’s designed for multiple people to use it at once; for things like sorting through vacation photos, or even playing animated digital board games, using physical accessories like special dice. (Lenovo calls this sort of hybrid activity “phygital,” a name which probably won’t catch on.)

What about the games and apps?

Thanks to Microsoft’s push for developers to make tablet apps, the Windows Market is starting to fill with touch titles. Lenovo is mostly pushing its own shop, however, run in partnership with Intel, which has “5,000+ multi-user entertainment apps.” It’s not clear how many of those are actually designed for the Horizon Table PC, but it comes with a selection of entertainment and children’s titles, and with the built-in BlueStacks player it should be able to run certain Android apps as well.

Is 27 inches a little too big?

The Asus Transformer AiO, also shown off at CES, is based on a similar concept. It’s an 18.4-inch all-in-one Windows 8 PC, where the screen can detach and become a huge (but not as huge) tablet. Most of the hardware is in the base station, but it can connect to it wirelessly inside the home, Wii U style. It also converts to an Android tablet, for use separate from the base station.

Jared Spurbeck is an open-source software enthusiast, who uses an Android phone and an Ubuntu laptop PC. He has been writing about technology and electronics since 2008.

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Chicago rapper facing jail for parole violation

CHICAGO (AP) — Chicago rapper Chief Keef has been taken into custody after a juvenile court judge decided a video of him firing a semiautomatic rifle at a New York gun range was a violation of probation.

The artist, real name Keith Cozart, was sentenced last year to 18 months' probation after his conviction on aggravated unlawful use of a weapon charges for pointing a gun at police officers.

The Chicago Sun-Times reports (http://bit.ly/VJ1YUt) Judge Carl Anthony Walker said the video showed a disregard for the court's authority. Walker scheduled a Thursday sentencing hearing for the 17-year-old Cozart.

Defense attorney Dennis Berkson told Walker his client never took the gun outside of the range and the target practice was supervised.

Chief Keef's first album, "Finally Rich," was released last year to mixed reviews.

___

Information from: Chicago Sun-Times, http://www.suntimes.com/index

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Breaking Link of Violence and Mental Illness

No one but a deeply disturbed individual marches into an elementary school or a movie theater and guns down random, innocent people.

That hard fact drives the public longing for a mental health system that produces clear warning signals and can somehow stop the violence. And it is now fueling a surge in legislative activity, in Washington and New York.

But these proposed changes and others like them may backfire and only reveal how broken the system is, experts said.

“Anytime you have one of these tragic cases like Newtown, it’s going to expose deficiencies in the mental health system, and provide some opportunity for reform,” said Richard J. Bonnie, a professor of public policy at the University of Virginia’s law school who led a state commission that overhauled policies after the 2007 Virginia Tech shootings that left 33 people dead. “But you have to be very careful not to overreact.”

New York State legislators on Tuesday passed a gun bill that would require therapists to report to the authorities any client thought to be “likely to engage in” violent behavior; under the law, the police would confiscate any weapons the person had.

And in Washington, lawmakers said that President Obama was considering a range of actions as part of a plan to reduce gun violence, including more sharing of records between mental health and law enforcement agencies.

The White House plan to make use of mental health data was still taking shape late Tuesday. But several ideas being discussed — including the reporting provision in the New York gun law — are deeply contentious and transcend political differences.

Some advocates favored the reporting provision as having the potential to prevent a massacre. Among them was D. J. Jaffe, founder of the Mental Illness Policy Org., which pushes for more aggressive treatment policies. Some mass killers “were seen by mental health professionals who did not have to report their illness or that they were becoming dangerous and they went on to kill,” he said.

Yet many patient advocates and therapists strongly disagreed, saying it would intrude into the doctor-patient relationship in a way that could dissuade troubled people from speaking their minds, and complicate the many judgment calls therapists already have to make.

The New York statute requires doctors and other mental health professionals to report any person who “is likely to engage in conduct that would result in serious harm to self or others.”

Under current ethical guidelines, only involuntary hospitalizations (and direct threats made by patients) are reported to the authorities. These reports then appear on a federal background-check database. The new laws would go further.

“The way I read the new law, it means I have to report voluntary as well as involuntary hospitalizations, as well as many people being treated for suicidal thinking, for instance, as outpatients,” said Dr. Paul S. Appelbaum, director of the Division of Law, Ethics, and Psychiatry at Columbia University’s medical school. “That is a much larger group of people than before, and most of whom will never be a serious threat to anyone.”

One fundamental problem with looking for “warning signs” is that it is more art than science. People with serious mental disorders, while more likely to commit aggressive acts than the average person, account for only about 4 percent of violent crimes over all.

The rate is higher when it comes to rampage or serial killings, closer to 20 percent, according to Dr. Michael Stone, a New York forensic psychiatrist who has a database of about 200 mass and serial killers. He has concluded from the records that about 40 were likely to have had paranoid schizophrenia or severe depression or were psychopathic, meaning they were impulsive and remorseless.

“But most mass murders are done by working-class men who’ve been jilted, fired, or otherwise humiliated — and who then undergo a crisis of rage and get out one of the 300 million guns in our country and do their thing,” Dr. Stone said.

The sort of young, troubled males who seem to psychiatrists most likely to commit school shootings — identified because they have made credible threats — often do not qualify for any diagnosis, experts said. They might have elements of paranoia, of deep resentment, or of narcissism, a grandiose self-regard, that are noticeable but do not add up to any specific “disorder” according to strict criteria.

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Facebook introduces new search tool

MENLO PARK, Calif. — Facebook Inc. has begun rolling out a new search feature that will eventually let 1 billion-plus users around the world unearth and sift through vast amounts of information that they and their friends have shared on the social network.

The new tool, dubbed Graph Search, takes aim at major rivals such as Google Inc. and promises to open up a whole new way of searching online. With the tool, users can find a single guy in San Francisco to date, a friend of a friend who knows of a job or friends who live in a 10-mile radius and are fans of "Game of Thrones."

"It's going to cause people to do all kinds of searches they have never done before because you couldn't do these searches before," said Danny Sullivan, founding editor of SearchEngineLand.com.

But the feature — Facebook's first major product launch since its rocky initial public stock offering in May — is already raising privacy concerns. It also did not immediately allay deep anxiety among investors over Facebook's moneymaking prospects.

Still, Facebook Chief Executive Mark Zuckerberg called it "one of the coolest things we've done in a while."

"Graph Search is a completely new way for people to get information on Facebook," Zuckerberg said.

For now, Facebook plans to roll it out slowly and said it could take more than a year for the search tool to reach all of its users around the globe. It plans to tweak the service to match how people use it.

If it proves popular, Facebook users may begin to spend more time on Facebook and less time elsewhere.

And that potentially threatens competitors — not just Internet search giant Google, which can't index the personal information on Facebook, but also other major players in Silicon Valley such as professional networking service LinkedIn Corp. and business review service Yelp Inc.

They aren't the only ones who may feel uneasy — at least at first. Facebook users will probably be wary of the new feature too. All of a sudden, Facebook pals will be able to easily uncover heaps of personal details about the user that already existed on Facebook but weren't quite so visible.

During an hourlong news conference at the company's Menlo Park, Calif., headquarters, Zuckerberg took pains to emphasize that the search feature was designed to give users control over the information people can search.

"We take this really seriously," he said.

Facebook is introducing the feature very slowly rather than flipping the switch overnight the way it did with News Feed to calm those fears, said Woodrow Hartzog, assistant law professor at Samford University in Birmingham, Ala. Graph Search will be available at first to only hundreds, or possibly thousands, of users, with more being gradually added over the coming weeks and months.

Hartzog said he expects Facebook users will eventually find the feature to be useful but would first have to overcome qualms over "a loss of obscurity."

"People who interact socially online respond much better when they have a little time to remove or make more obscure information that is going to become more obvious with a particular technology," Hartzog said.

But privacy watchdog Marc Rotenberg said Facebook is giving users whiplash by "constantly changing the rules for access to user data."

"And Facebook telling users that it's on them to check their privacy setting is not right," said Rotenberg, executive director of the Electronic Privacy Information Center.

Zuckerberg said the initial rollout marks the beginning of Facebook's years-long investment in Graph Search that will eventually be available on mobile and in more languages.

The feature has been in the works for years. Current rudimentary search capability on Facebook has been clunky and mostly useless.

The effort kicked into high gear in spring 2011, when Zuckerberg recruited Lars Rasmussen from Google to join Facebook's search team. Rasmussen's challenge: to make it easier for Facebook users to discover information about the people they care about and connect with people with similar interests. Rasmussen was soon joined by another former Google employee, Tom Stocky.

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Saving this dinosaur took a skeleton crew

The urgent message went well beyond Robert Painter's usual areas of legal expertise — personal injury, commercial disputes, medical malpractice.

In less than 48 hours, the skeleton of a Tyrannosaurus bataar, a fierce cousin of Tyrannosaurus rex, would be up for auction.

"Sorry for the late notice," the email said. "Is there anything we can do to legally stop this?"

The president of Mongolia, whom Painter had met 10 years before at a public policy conference, was now asking the Houston lawyer to block the sale of a fossil that scientists believed had been looted from the Gobi Desert. The auction catalog described the specimen:

"The quality of the preservation is superb, with wonderful bone texture and delightfully mottled grayish bone color. In striking contrast are those deadly teeth, long and frightfully robust, in a warm woody brown color, the fearsome, bristling mouth and monstrous jaws leaving one in no doubt as to how the creature came to rule its food chain."

The sheer size and condition of the fossil seemed guaranteed to fetch a seven-figure price. When Painter read the email May 18, it was already 6:30 p.m. on a Friday. The auction was Sunday.

In the days that followed, Painter, a New York auctioneer, a Texas judge, federal prosecutors, the Mongolian president and a self-described "commercial paleontologist" would come together somewhat like the skeleton they were fighting for, disparate parts brought together through dogged effort and mysterious circumstances.

The fight would play out in federal courts in a case known as United States of America vs. One Tyrannosaurus Bataar Skeleton.

***

Since 1924, the Mongolian constitution has classified dinosaur fossils as "culturally significant," meaning they cannot be taken from the country without government permission. Over the years, the punishment for illegally keeping or smuggling dinosaur bones has varied from up to seven years in prison to 500 hours of forced labor or paying up to 500,000 tugriks, the Mongolian currency. (That's about $356.50.)

Cultural heritage is a sensitive subject for a people who, their history of Genghis Khan's empire-building notwithstanding, saw powerful, aggressive neighbors invade their lands repeatedly.

After advertising for the auction caught the attention of paleontologists worldwide, Mongolian officials and journalists quickly learned of the fossil with the "delightfully mottled grayish bone color."

"The dinosaur has the color of the Gobi sand," said Oyungerel Tsedevdamba, an advisor to Mongolian President Tsakhiagiin Elbegdorj. "Such color is very particular and familiar to us and belongs to this country."

On May 18, as Tsedevdamba was preparing to leave her home in the Mongolian capital, Ulan Bator, for a meeting, her husband, a science enthusiast, pointed out a news report he'd found online: A Tyrannosaurus bataar was going to be auctioned in New York.

Auctioned fossils are usually too expensive for universities to buy, and private sellers typically don't provide enough details on how or where they got them. That leaves many of the bones in the hands of wealthy fossil buffs, or museums that look the other way.

"Technically, public institutions are neither ethically allowed to own poached specimens, nor are scientists supposed to publish on poached specimens," said Philip Currie, a University of Alberta paleontologist who studied the Gobi Desert region for 15 years. "In other words, they become scientifically useless."

The Tyrannosaurus bataar was 24 feet long, stood 8 feet high and weighed two tons. Still, the beast was only two-thirds grown when it died 70 million years ago.

Though it never grew into a 34-foot adult, the Tyrannosaurus thrived on the abundant prey attracted to the Nemegt Basin, then a lush river plain that straddled what is today the Gobi Desert on the Mongolia-China border. The carnivore's main competitors were its own kind.

The creature's jaw still carries bite marks, apparently inflicted by another Tyrannosaurus bataar.

These predators were "scrappy," Currie said. "They weren't overly playful."

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TSX off 10-month high, energy weakness offsets RIM jump

TORONTO (Reuters) – Canada‘s main stock index finished short of a 10-month high on Monday as investor optimism for Research In Motion Ltd shares over the upcoming launch of its BlackBerry 10 devices was offset by falling energy shares.

Weakness in the materials sector, which includes mining stocks, also added pressure, while volatile oil prices were a drag on the energy sector. The two heavyweight sectors kept an otherwise positive index in check.

RIM shares extended a 13-percent gain made on Friday. The stock added 10.44 percent to C$ 14.70 and helped the information technology sector gain 2.48 percent.

“The investor confidence is brought about simply because of hope, and hope that the new BlackBerry 10 is going to be an answer to their prayers,” said Fred Ketchen, director of equity trading at ScotiaMcLeod.

“There has been some talk that this is a revival of RIM. We’ll have to wait and see,” he added.

The Toronto Stock Exchange‘s S&P/TSX composite index <.gsptse> finished little changed, up a 0.91 of a point, or 0.01 percent, at 12,603.09. Earlier, it touched 12,636.68, its highest since March 5, 2012.</.gsptse>

The index, which marked its fifth consecutive day of gains, swung back and forth between positive and negative territories in choppy trade.

“There’s a lot of indecisiveness out there. People don’t really know which way to go and you’re getting these markets that aren’t really doing much of anything,” said Julie Brough, vice president at Morgan Meighen & Associates.

Investors kept a close watch on the U.S. debt ceiling talks, seen as a significant catalyst for the markets, with hopes that a compromise will be reached. “There is reasonable optimism that it would be resolved,” Brough said.

The energy sector was down 0.5 percent, with Canadian Natural Resources Ltd slipping 1.81 percent to C$ 29.26 and Talisman Energy Inc falling 2.64 percent to C$ 11.78. Oil prices were volatile, with Brent crude rising to $ 112 on supply concerns.

Encana Corp shares dropped 2.31 percent to C$ 19.05 after the surprise resignation of the chief executive officer of Canada’s largest natural gas producer.

The three energy companies were the three biggest drags on the index.

Materials stocks, home to mining firms, was down 0.3 percent amid a slew of deals within the sector.

Miner Alamos Gold Inc said it will buy Aurizon Mines Ltd for about C$ 780 million ($ 793 million) in cash and stock to get access to Aurizon’s only operating gold mine, Casa Berardi, in northern Quebec. Aurizon shares jumped 34 percent to C$ 4.57, while Alamos Gold fell 11.94 percent to C$ 14.90.

Russia’s state uranium firm agreed to pay $ 1.3 billion to take Canada’s Uranium One Inc private, as the successor to the Soviet Union’s nuclear industry seeks to strengthen its grip on supplies. Uranium One’s stock rose 14.52 percent to C$ 2.76.

In other company news, shares of Harry Winston Diamond Corp rose 4.41 percent to C$ 14.90 on the company’s plans to sell its high-end watches-to-necklaces division to Swatch Group in a $ 750 million cash deal that expands the Swiss watchmaker’s luxury offering and lets the Canadian group concentrate on its diamond mines.

(Additional reporting by Solarina Ho; Editing by James Dalgleish and Nick Zieminski)

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AP source: Armstrong tells Oprah Winfrey he doped

AUSTIN, Texas (AP) — After a decade of denial, Lance Armstrong has finally come clean: He used performance-enhancing drugs to win the Tour de France.

The disgraced cyclist made the confession to Oprah Winfrey during an interview taped Monday, a person familiar with the situation told The Associated Press. The person spoke on condition of anonymity because the interview is to be broadcast Thursday on Winfrey's network.

The admission Monday came hours after an emotional apology by Armstrong to the Livestrong charity that he founded and took global on the strength of his celebrity as a cancer survivor who came back to win one of sport's most grueling events.

The confession was a stunning reversal, after years of public statements, interviews and court battles in which he denied doping and zealously protected his reputation.

Winfrey tweeted afterward, "Just wrapped with (at)lancearmstrong More than 2 1/2 hours. He came READY!" She was scheduled to appear on "CBS This Morning" on Tuesday to discuss the interview.

Even before the taping session with Winfrey began around 2 p.m., EST, Armstrong's apology suggested he would carry through on promises over the weekend to answer her questions "directly, honestly and candidly."

The cyclist was stripped of his Tour de France titles, lost most of his endorsements and was forced to leave the foundation last year after the U.S. Anti-Doping Agency issued a damning, 1,000-page report that accused him of masterminding a long-running doping scheme.

About 100 staff members of the charity Armstrong founded in 1997 gathered in a conference room as Armstrong arrived with a simple message: "I'm sorry." He choked up during a 20-minute talk, expressing regret for the long-running controversy tied to performance-enhancers had caused, but stopped short of admitting he used them.

Before he was done, several members were in tears when he urged them to continue the charity's mission, helping cancer patients and their families.

"Heartfelt and sincere," is how Livestrong spokesman Katherine McLane described his speech.

Armstrong later huddled with almost a dozen people before stepping into a room set up at a downtown Austin hotel for the interview.

The group included close friends and advisers, two of his lawyers and Bill Stapleton, his agent, manager and business partner. They exchanged handshakes and smiles, but declined comment when approached by a reporter. Most members of that group left the hotel through the front entrance around 5 p.m., although Armstrong was not with them.

No further details about the interview were available immediately because of confidentiality agreements signed by both camps. But Winfrey promoted it as a "no-holds barred" session, and after the voluminous USADA report — which included testimony from 11 former teammates — she had plenty of material for questions. USADA chief executive Travis Tygart, a longtime critic of Armstrong's, called the drug regimen practiced while Armstrong led the U.S. Postal Service team, "The most sophisticated, professionalized and successful doping program that sport has ever seen."

Armstrong also went after his critics ruthlessly during his reign as cycling champion. He scolded some in public and didn't hesitate to punish outspoken riders during the race itself. He waged legal battles against still others in court.

Betsy Andreu, the wife of former Armstrong teammate Frankie Andreu, was one of the first to publicly accuse Armstrong of using performance-enhancing drugs. She called news of Armstrong's confession "very emotional and very sad," and got choked up as well when asked to comment.

"He used to be one of my husband's best friends and because he wouldn't go along with the doping, he got kicked to the side. Lance could have a positive impact if he tells the truth on everything. He's got to be completely honest," she said.

At least one of his opponents, the London-based Sunday Times, has already filed a lawsuit to recover about $500,000 it paid him to settle a libel case, and Dallas-based SCA Promotions, which tried to deny Armstrong a promised bonus for a Tour de France win, has threatened to bring yet another lawsuit seeking to recover more than $7.5 million an arbitration panel awarded the cyclist in that dispute.

In addition, former teammate Floyd Landis, who was stripped of the 2006 Tour de France title for doping, has filed a federal whistle-blower lawsuit that accused Armstrong of defrauding the U.S. Postal Service. The Justice Department has yet to decide whether it will join the suit as a plaintiff.

The lawsuit most likely to be influenced by a confession might be the Sunday Times case. Potential perjury charges stemming from Armstrong's sworn testimony in the 2005 arbitration fight would not apply because of the statute of limitations. Armstrong was not deposed during the federal investigation that was closed last year.

Armstrong is said to be worth around $100 million. But most sponsors dropped him after USADA's scathing report — at the cost of tens of millions of dollars — and soon after, he left the board of Livestrong.

After the USADA findings, he was also barred from competing in the elite triathlon or running events he participated in after his cycling career. World Anti-Doping Code rules state his lifetime ban cannot be reduced to less than eight years. WADA and U.S. Anti-Doping officials could agree to reduce the ban further depending on what information Armstrong provides and his level of cooperation.

Whether his confession would begin to heal those ruptures and restore that reputation remains to be seen.

Diagnosed with testicular cancer in October 1996, the disease soon spread to his lungs and brains. Armstrong's doctors gave him a 40 percent chance of survival at the time and never expected he'd compete at anything more strenuous than gin rummy. Winning the demanding race less than three years later made Armstrong a hero.

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Jim Litke reported from Chicago.

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